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The Annals of Thoracic Surgery, Vol 46, 661-665, Copyright © 1988 by The Society of Thoracic Surgeons
EL Hoover, B Kharma, M Ross, H Webb, HK Hsu, L Clark, B Toporoff and JN Cunningham
We studied the effects of intraaortic balloon counterpulsation (IABCP) on
prostacyclin (PGI2) and thromboxane (TXB2) levels in dogs during 24 hours
of 1:1 IABCP or a sham procedure in which the balloon was positioned but
left deflated. The arterial PGI2 levels in the IABCP group increased from
control values of 95 +/- 20 pg/ml to 268 +/- 95 pg/ml at 1 hour, 429 +/- 95
pg/ml at 4 hours, and 1,884 +/- 532 pg/ml at 24 hours. The arterial PGI2
levels were consistently higher in the IABCP group. Although the TXB2
measurements revealed no significant differences between groups, the IABCP
group consistently had a higher level than the sham group. The platelet
count in the control group decreased to 45% of baseline levels versus 55%
for the IABCP group. We conclude that prolonged IABCP results in either net
production of PGI2 or decreased degradation. The correlation between TXB2
and platelet counts is unclear and remains to be defined.
ARTICLES
The temporal relationship in arterial and venous prostacyclin and thromboxane activity during 24 hours of intraaortic balloon counterpulsation in dogs
Department of Surgery, Meharry Medical College, Nashville, TN 37208.
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