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The Annals of Thoracic Surgery, Vol 46, 603-610, Copyright © 1988 by The Society of Thoracic Surgeons
T Naruke, T Goya, R Tsuchiya and K Suemasu
In the past 25 years, 1,654 patients with non-small cell cancer underwent
resection at National Cancer Center Hospital, Tokyo. A comparative study
has been made of 5-year survival of patients who had pulmonary resection
with and without mediastinal lymph node dissection. There were 426 patients
(25.8% of the total) with N2 M0 disease. Of these, 345 underwent pulmonary
resection with mediastinal lymph node dissection. The 5-year survival in
this group was 15.9% (T1 N2 M0, 30.0%; T2 N2 M0, 14.5%; and T3 N2 M0,
12.9%). In the remaining 81 patients, who did not have mediastinal lymph
node dissection, 5-year survival was 6.7%. Of the 426 patients with N2 M0
disease, 242 were select patients who underwent a curative operation with
an overall 5- year survival of 19.2%. Sixty-six of them had squamous cell
carcinoma and a 5-year survival of 30.8%; 153 had adenocarcinoma and a
survival of 16.0%; 14 had large cell carcinoma and a survival of 12.8%; and
9 had adenosquamous cell carcinoma, and none survived 5 years. To improve
the end results, it is important to perform as many curative operations
with mediastinal lymph node dissection as possible. Histological cell type
and tumor status must be taken into consideration.
ARTICLES
The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis
Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
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P. Goldstraw, G. C. Mannam, D. K. Kaplan, and P. Michail Surgical management of non-small-cell lung cancer with ipsilateral mediastinal node metastasis (N2 disease) J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 19 - 28. [Abstract] [Full Text]
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T. Funatsu The role of mediastinoscopic biopsy in preoperative assessment of lung cancer J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 309 - 311. [Full Text]
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