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The Annals of Thoracic Surgery, Vol 46, 40-44, Copyright © 1988 by The Society of Thoracic Surgeons

ARTICLES

Chest wall resection for Ewing's sarcoma of the rib: an unnecessary procedure

BN Rao, FA Hayes, EI Thompson, AP Kumar, ID Fleming, AA Green, BA Austin, JW Pate and HO Hustu
Division of Surgery, Hematology-Oncology, and Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101.

Approximately 10% of all cases of Ewing's sarcoma arise from a rib. Conventional management has included chest wall resection (3 or more ribs) and radiation therapy. These forms of therapy have led to complications such as scoliosis and local deformity. The addition of radiation therapy can result in damage to the lung and adjacent viscera and also potentiate pulmonary restrictive disease. Between 1971 and 1978, 9 patients were treated with surgery, radiation therapy, and combination chemotherapy (three- or four-drug regimen). Only 2 patients (22%) survive. Since 1979, 14 patients were entered into a new protocol consisting of sequential induction chemotherapy, followed by delayed surgical resection whenever feasible. Three patients had complete resection of their primary lesion at onset. Initially, 7 patients had either biopsy (N = 4) or incomplete chest wall resection N = 3). All 4 patients with biopsy only at diagnosis had excellent responses to induction chemotherapy, allowing delayed resection of the involved rib without chest wall resection. Overall, 12 of 14 patients (86%) treated since 1979 survive, with only 2 receiving radiation therapy for residual disease in the primary rib site.

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