HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Diehl, J. T. Articles by Connolly, R. J. Search for Related Content PubMed PubMed Citation Articles by Diehl, J. T. Articles by Connolly, R. J.

The Annals of Thoracic Surgery, Vol 45, 595-602, Copyright © 1988 by The Society of Thoracic Surgeons

ARTICLES

Efficacy of retrograde coronary sinus cardioplegia in patients undergoing myocardial revascularization: a prospective randomized trial

JT Diehl, EJ Eichhorn, MA Konstam, DD Payne, AR Dresdale, RM Bojar, H Rastegar, JJ Stetz, DN Salem and RJ Connolly
Department of Cardiothoracic Surgery, New England Medical Center Hospital, Boston, MA 02111.

The efficacy of retrograde coronary sinus cardioplegia (RCSC) administered through the right atrium compared with aortic root cardioplegia (ARC) has not been examined critically in patients undergoing coronary artery bypass grafting (CABG). Twenty patients having elective CABG were randomized prospectively to receive cold blood ARC (Group I, 10 patients) or cold blood RCSC (Group II, 10 patients). Patient demographics were similar in both groups. Ventricular function was assessed preoperatively by radionuclide ventriculography and postoperatively by simultaneous hemodynamic and radionuclide ventriculographic studies with volume loading. There was no change in ejection fraction (EF) (preoperative versus postoperative value) in Group I (50 +/- 6% versus 53 +/- 6%) but in group II, at similar peak systolic pressure and similar left ventricular end- diastolic volume index (LVEDVI), LVEF improved significantly (49 +/- 6% versus 60 +/- 12%, p less than 0.05). Postoperative ventricular function (stroke work index versus EDVI) for the left ventricle and right ventricle were similar in both groups. Evaluation of postoperative LV systolic function (end-systolic blood pressure versus end-systolic volume index) and diastolic function (pulmonary capillary wedge pressure versus EDVI) were also similar in both groups. Retrograde coronary sinus cardioplegia is as effective as ARC for intraoperative myocardial protection, and provides excellent postoperative function in patients undergoing elective CABG.

This article has been cited by other articles:

				P. Ruengsakulrach and B. F. Buxton Anatomic and hemodynamic considerations influencing the efficiency of retrograde cardioplegia Ann. Thorac. Surg., April 1, 2001; 71(4): 1389 - 1395. [Abstract] [Full Text] [PDF]

				N. G. Talwalkar, G. M. Lawrie, N. Earle, and M. E. DeBakey Can Retrograde Cardioplegia Alone Provide Adequate Protection for Cardiac Valve Surgery? Chest, January 1, 1999; 115(1): 135 - 139. [Abstract] [Full Text] [PDF]

				M. Carrier, L. C. Pelletier, and N. R. Searle Does Retrograde Administration of Blood Cardioplegia Improve Myocardial Protection During First Operation for Coronary Artery Bypass Grafting? Ann. Thorac. Surg., November 1, 1997; 64(5): 1256 - 1262. [Abstract] [Full Text]

				K. V. Arom, R. W. Emery, R. J. Petersen, and J. W. Bero Evaluation of 7,000+ Patients With Two Different Routes of Cardioplegia Ann. Thorac. Surg., June 1, 1997; 63(6): 1619 - 1624. [Abstract] [Full Text]

				R. N. Gates, J. Lee, H. Laks, D. C. Drinkwater Jr, E. Rhudis, A. S. Aharon, J. Y. Chung, and P. A. Chang Evidence of Improved Microvascular Perfusion When Using Antegrade and Retrograde Cardioplegia Ann. Thorac. Surg., November 1, 1996; 62(5): 1388 - 1391. [Abstract] [Full Text]

				C. Quintilio, P. Voci, F. Bilotta, G. Luzi, F. Chiarotti, M. C. Acconcia, C. Mercanti, and B. Marino Risk factors of incomplete distribution of cardioplegic solution during coronary artery grafting J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 439 - 447. [Abstract] [Full Text]

				O. Jegaden, A. Eker, P. Montagna, J. Ossette, C. Vial, J. Guidollet, and P. H. Mikaeloff Antegrade/Retrograde Cardioplegia in Arterial Bypass Grafting: Metabolic Randomized Clinical Trial Ann. Thorac. Surg., February 1, 1995; 59(2): 456 - 461. [Abstract] [Full Text]

				J. Eng and C. Munsch Retrograde cardioplegia Perfusion, January 1, 1992; 7(1): 7 - 12. [PDF]