HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fraser, C. D. Articles by Baumgartner, W. A. Search for Related Content PubMed PubMed Citation Articles by Fraser, C. D., Jr Articles by Baumgartner, W. A.

The Annals of Thoracic Surgery, Vol 45, 253-257, Copyright © 1988 by The Society of Thoracic Surgeons

ARTICLES

Donor core-cooling provides improved static preservation for heart-lung transplantation

CD Fraser Jr, F Tamura, H Adachi, GJ Kontos Jr, J Brawn, GM Hutchins, AM Borkon, BA Reitz and WA Baumgartner
Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, MD.

Twenty-three dairy calves underwent heart-lung allotransplantation after donor organs were procured using either donor core-cooling through cardiopulmonary bypass (CPB) or pulmonary artery flush (PAF) to assess which method provides optimal graft preservation. In Groups 1 (control) and 2, donors were cooled to 15 degrees C on CPB and organs were either immediately transplanted (Group 1) or stored in saline solution (4 degrees C) for 4 hours (Group 2) prior to transplantation. In Group 3, donors were pretreated with prostaglandin E1 prior to PAF with modified Euro-Collins solution. Organs were stored in saline solution (4 degrees C) for 4 hours and were then transplanted. Acute cardiopulmonary function following transplantation was assessed by the ratio of end-systolic pressure to end-systolic dimension, extravascular lung water (EVLW), lung compliance, arterial oxygenation, and lung biopsy. Cardiac function after the transplantation procedure was similar in all groups, but EVLW values and lung biopsy scores were worse after PAF. Arterial O2 tension appeared lower after PAF, but not significantly so. Core-cooling provides superior static preservation and thus improved graft function in the acute bovine model.

This article has been cited by other articles:

				L. K. von Segesser Cardiopulmonary support and extracorporeal membrane oxygenation for cardiac assist Ann. Thorac. Surg., August 1, 1999; 68(2): 672 - 677. [Abstract] [Full Text] [PDF]