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The Annals of Thoracic Surgery, Vol 45, 203-205, Copyright © 1988 by The Society of Thoracic Surgeons

ARTICLES

The effectiveness of fibrin glue sealant for reducing experimental pulmonary ari leak

PM McCarthy, VF Trastek, DG Bell, GR Buttermann, JM Piehler, WS Payne, LH Weiland and PC Pairolero
Section of Thoracic and Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55905.

The effectiveness of fibrin glue as a biological sealant for pulmonary air leaks was determined in 16 dogs. A standardized pleural defect was made in the left lower lobe, and the quantity of air passing through a chest tube was assessed with a Collins respirometer. For the 8 randomly assigned control animals, the air leak decreased over 90 minutes from a mean of 1.4 L/min to a mean of 1.1 L/min (mean decrease, 19.8%). In the 8 randomly assigned fibrin glue-treated animals, the air leak decreased from a mean of 2.1 L/min to a mean of 0.5 L/min (mean decrease, 80.8%) (p less than 0.0001). Postoperative evaluation of survivors disclosed no increased adhesions in the glue-treated animals and complete resorption of the glue at 3 months. We conclude that in this animal model, fibrin glue reduced the size of pulmonary air leaks in the early period after thoracotomy and did not lead to increased intrapleural adhesions.

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