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The Annals of Thoracic Surgery, Vol 41, 106-112, Copyright © 1986 by The Society of Thoracic Surgeons

ARTICLES

Antiarrhythmic drugs: electrophysiological basis of their clinical usage

JT Weng, DE Smith and PV Moulder

Cardiac arrhythmias arise from abnormalities of impulse initiation or impulse conduction or both. A review of the electrophysiological mechanisms of the genesis of cardiac arrhythmias and of the electrophysiological principles of the treatment of the cardiac arrhythmias leads to: categorization of antiarrhythmic drugs into five classes based on their dominant cardiac electrophysiological actions; a series of categories of their effects on impulse initiation and impulse conduction in different types of cardiac cells; and a systematic approach to pharmacological management of cardiac arrhythmias.




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Copyright © 1986 by The Society of Thoracic Surgeons.