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The Annals of Thoracic Surgery, Vol 40, 261-263, Copyright © 1985 by The Society of Thoracic Surgeons

ARTICLES

Coronary bypass surgery in patients with circulating lupus anticoagulant

JP Kelly, L Thomas, PV Moulder and WR Webb

Clinical and laboratory experience with circulating lupus anticoagulant in 3 patients undergoing coronary artery bypass procedures is reported. This circulatory anticoagulant inhibits activation of prothrombin by the prothrombin activator complex (factor Xa, factor V, and phospholipid). The presence of lupus anticoagulant was initially detected because of a prolonged activated partial thromboplastin time and a normal or mildly prolonged prothrombin time. The 3 patients underwent uncomplicated coronary artery bypass grafting and experienced no abnormal bleeding postoperatively. The lupus anticoagulant is a rare cause of bleeding after open-heart surgery. It appears to be a problem only when an additional coagulation defect is present.


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A. H Stammers, R P. Dorion, C. Trowbridge, B. Yen, M. Klayman, J. D Murdock, E. Woods, and C. Gilbert
Coagulation management of a patient with factor V Leiden mutation, lupus anticoagulant, and activated protein C resistance: a case report
Perfusion, March 1, 2005; 20(2): 115 - 120.
[Abstract] [PDF]


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Copyright © 1985 by The Society of Thoracic Surgeons.