HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, M. E. Articles by Gray, R. J. Search for Related Content PubMed PubMed Citation Articles by Lee, M. E. Articles by Gray, R. J.

The Annals of Thoracic Surgery, Vol 35, 277-279, Copyright © 1983 by The Society of Thoracic Surgeons

ARTICLES

CK-MB release following coronary artery bypass grafting in the absence of myocardial infarction

ME Lee, DH Sethna, CM Conklin, WE Shell, JM Matloff and RJ Gray

Elevation of levels of the myocardial-specific isoenzyme of creatine kinase (CK-MB) in the immediate postoperative period in patients undergoing coronary artery bypass grafting is usually associated with myocardial necrosis. However, mean isoenzyme elevations of 18 +/- 2 IU/L (standard error of the mean) were recently observed in 6 patients in the absence of electrocardiographic or scintigraphic (technetium 99m stannous pyrophosphate) evidence of perioperative myocardial infarction. To test the hypothesis that surgical trauma of the atrium and aorta during cannulation for cardiopulmonary bypass might contribute to elevated CK-MB levels, biopsy of the right atrial appendage and aorta of 7 patients was done at operation, the tissue samples were assayed for total creatine kinase (CK) activity using the Rosalki technique, and for CK-MB using column chromatography. The results indicate that the human atrium is a rich source of CK, with the proportion of CK-MB similar to that present in the ventricle (20%). In addition, technical considerations inherent in the performance of coronary bypass surgery may result in release of CK-MB, causing elevated serum enzyme levels in the post-coronary artery bypass patient in the absence of myocardial infarction.

This article has been cited by other articles:

				M. Kuduvalli, N. Newall, A. Stott, A. D. Grayson, and B. M. Fabri Impact of avoiding cardiopulmonary bypass for coronary surgery on perioperative cardiac enzyme release and survival. Eur. J. Cardiothorac. Surg., May 1, 2006; 29(5): 729 - 735. [Abstract] [Full Text] [PDF]

				M. C. Engoren, R. H. Habib, A. Zacharias, T. A. Schwann, C. J. Riordan, S. J. Durham, and A. Shah The association of elevated creatine kinase-myocardial band on mortality after coronary artery bypass grafting surgery is time and magnitude limited Eur. J. Cardiothorac. Surg., July 1, 2005; 28(1): 114 - 119. [Abstract] [Full Text] [PDF]

				T. Backstrom, M. Goiny, U. Lockowandt, J. Liska, and A. Franco-Cereceda Cardiac outflow of amino acids and purines during myocardial ischemia and reperfusion J Appl Physiol, March 1, 2003; 94(3): 1122 - 1128. [Abstract] [Full Text] [PDF]

				M. A. Costa, R. G. Carere, S. V. Lichtenstein, D. P. Foley, V. de Valk, W. Lindenboom, P. C.H. Roose, T. R. van Geldorp, C. Macaya, J. L. Castanon, et al. Incidence, Predictors, and Significance of Abnormal Cardiac Enzyme Rise in Patients Treated With Bypass Surgery in the Arterial Revascularization Therapies Study (ARTS) Circulation, November 27, 2001; 104(22): 2689 - 2693. [Abstract] [Full Text] [PDF]

				T. A Abdel Aziz, M. A Ali, D. G Roberts, N. Al Khaja, T. A Abdel Aziz, M. A Ali, D. G Roberts, and N. Al Khaja Troponin T as a Marker of Infarction During Coronary Bypass Surgery Asian Cardiovasc Thorac Ann, March 1, 2000; 8(1): 19 - 23. [Abstract] [Full Text] [PDF]