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The Annals of Thoracic Surgery, Vol 28, 28-32, Copyright © 1979 by The Society of Thoracic Surgeons
JJ Lamberti, BH Wainer, KA Fisher, HB Karunaratne and J Al-Sadir
We have encountered two cases of late calcification of the porcine
heterograft. A patient in chronic renal failure died of sepsis and
endocarditis fifteen months after replacement of the mitral and tricuspid
valves. At postmortem examination, both heterograft valves exhibited severe
calcification and thrombosis. A second patient with rheumatic heart disease
and sickle cell disease underwent mitral valve replacement for severe
regurgitation. Thirty months later, cardiac catheterization revealed
prosthetic valve stenosis. The valve was replaced successfully, and the
excised heterograft exhibited severe calcification with restriction of
leaflet motion. Although calcification of the porcine heterograft is known
to occur in patients with infection or disorders of calcium metabolism,
dysfunction of the heterograft is rare in our experience.
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Calcific stenosis of the porcine heterograft
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