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The Annals of Thoracic Surgery, Vol 25, 541-550, Copyright © 1978 by The Society of Thoracic Surgeons

ARTICLES

A comparison between propranolol and hypothermia in preventing ischemic contracture of the left ventricle (stone heart)

GL Zumbro Jr, L Tillman, AO Bailey 3d and RL Treasure

Ischemic contracture of the left ventricle ("stone heart") was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly.




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Copyright © 1978 by The Society of Thoracic Surgeons.