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The Annals of Thoracic Surgery, Vol 23, 374-375, Copyright © 1977 by The Society of Thoracic Surgeons

ARTICLES

Hemolysis due to chemical contamination of clinical perfusion apparatus

DF Larson, B Mayall and RM Anderson

A chemical contaminant found on the interior surface of the extracorporeal apparatus manufactured by the William Harvey Corporation was believed to have caused severe hematuria in 2 children. The biological activity of the contaminant was tested by mixing 50 ml of whole blood in contaminated cardiotomies; after 5 minutes of exposure lysis of one-sixth of the red blood cells was found. This hemolytic agent was concluded to be bisphenol A dissolved in an organic solvent, but the mechanism of contamination was never found.


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A. D. Papaconstantinou, T. H. Umbreit, B. R. Fisher, P. L. Goering, N. T. Lappas, and K. M. Brown
Bisphenol A-Induced Increase in Uterine Weight and Alterations in Uterine Morphology in Ovariectomized B6C3F1 Mice: Role of the Estrogen Receptor
Toxicol. Sci., August 1, 2000; 56(2): 332 - 339.
[Abstract] [Full Text] [PDF]


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Copyright © 1977 by The Society of Thoracic Surgeons.